Duloxetine (Oral Route) Before Using (2024)

Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of duloxetine in children to treat anxiety in children 7 years of age and older. However, safety and efficacy have not been established in children younger than 7 years of age.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of duloxetine in children to treat fibromyalgia in children 13 years of age and older. However, safety and efficacy have not been established in children younger than 13 years of age.

Appropriate studies have not been performed on the relationship of age to the effects of duloxetine for other indications in the pediatric population. Safety and efficacy have not been established for other indications.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of duloxetine in the elderly. However, elderly patients may be more sensitive to the effects of this medicine than younger adults, and are more likely to have hyponatremia (low sodium in the blood) and increase risk for falls, which may require caution in patients receiving duloxetine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bromopride
Eliglustat
Isocarboxazid
Linezolid
Mavorixafor
Methylene Blue
Metoclopramide
Ozanimod
Phenelzine
Procarbazine
Rasagiline
Safinamide
Selegiline
Thioridazine
Tranylcypromine
Viloxazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abciximab
Abiraterone Acetate
Aceclofenac
Acemetacin
Alfentanil
Almotriptan
Amineptine
Amitriptyline
Amitriptylinoxide
Amoxapine
Amphetamine
Amtolmetin Guacil
Anagrelide
Anileridine
Apixaban
Ardeparin
Aripiprazole
Asenapine
Aspirin
Atomoxetine
Benzhydrocodone
Benzphetamine
Betrixaban
Brexpiprazole
Bromfenac
Brompheniramine
Bufexamac
Buprenorphine
Bupropion
Buspirone
Butorphanol
Cangrelor
Capmatinib
Carbamazepine
Carvedilol
Celecoxib
Certoparin
Chlorpheniramine
Chlorpromazine
Choline Salicylate
Cifenline
Cilostazol
Cimetidine
Ciprofloxacin
Citalopram
Clomipramine
Clonixin
Clopidogrel
Clozapine
Cocaine
Codeine
Cyclobenzaprine
Dacomitinib
Deferasirox
Desipramine
Desvenlafaxine
Deutetrabenazine
Dexibuprofen
Dexketoprofen
Dextroamphetamine
Dextromethorphan
Dibenzepin
Diclofenac
Difenoxin
Diflunisal
Dihydrocodeine
Diphenoxylate
Dipyridamole
Dipyrone
Dixyrazine
Dolasetron
Donepezil
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Droxicam
Edoxaban
Eletriptan
Encainide
Enclomiphene
Enoxacin
Epoprostenol
Eptifibatide
Escitalopram
Ethylmorphine
Etodolac
Etofenamate
Etoricoxib
Fedratinib
Felbinac
Fenfluramine
Fenoprofen
Fentanyl
Fepradinol
Feprazone
Flecainide
Floctafenine
Flufenamic Acid
Fluoxetine
Fluphenazine
Flurbiprofen
Fluvoxamine
Frovatriptan
Gepirone
Givosiran
Granisetron
Haloperidol
Hydrocodone
Hydromorphone
Hydroxytryptophan
Ibuprofen
Iloperidone
Iloprost
Imipramine
Indecainide
Indomethacin
Iobenguane I 123
Iobenguane I 131
Ketobemidone
Ketoprofen
Ketorolac
Lasmiditan
Levoketoconazole
Levomilnacipran
Levorphanol
Lisdexamfetamine
Lithium
Lofepramine
Lofexidine
Lorcainide
Lorcaserin
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Melitracen
Meloxicam
Meperidine
Metaxalone
Methadone
Methamphetamine
Methdilazine
Methotrexate
Methotrimeprazine
Methoxyphenamine
Metopimazine
Metoprolol
Mexiletine
Milnacipran
Mirtazapine
Morniflumate
Morphine
Morphine Sulfate Liposome
Nabumetone
Nalbuphine
Naproxen
Naratriptan
Nebivolol
Nefazodone
Nepafenac
Nicergoline
Nicomorphine
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Nortriptyline
Oliceridine
Ondansetron
Opipramol
Opium
Opium Alkaloids
Oxaprozin
Oxycodone
Oxymorphone
Oxyphenbutazone
Pacritinib
Palonosetron
Papaveretum
Parecoxib
Paregoric
Parnaparin
Paroxetine
Pentazocine
Perazine
Perphenazine
Phenylbutazone
Piketoprofen
Pimozide
Piperazine
Pipotiazine
Piritramide
Piroxicam
Pitolisant
Pixantrone
Prajmaline
Pranoprofen
Prasugrel
Prochlorperazine
Proglumetacin
Promazine
Promethazine
Propafenone
Propiomazine
Propyphenazone
Proquazone
Protriptyline
Quinidine
Recainam
Remifentanil
Reviparin
Risperidone
Ritlecitinib
Rivaroxaban
Rizatriptan
Rofecoxib
Salicylic Acid
Salsalate
Selexipag
Sertraline
Sibutramine
Sodium Salicylate
St John's Wort
Sufentanil
Sulfinpyrazone
Sulindac
Sulodexide
Sumatriptan
Tamoxifen
Tapentadol
Tenoxicam
Thiethylperazine
Thioproperazine
Tianeptine
Tiaprofenic Acid
Ticagrelor
Ticlopidine
Tilidine
Timolol
Tirofiban
Tolfenamic Acid
Tolmetin
Tolperisone
Tolterodine
Tramadol
Trazodone
Treprostinil
Trifluoperazine
Triflupromazine
Trimipramine
Tropisetron
Tryptophan
Valdecoxib
Venlafaxine
Vernakalant
Vilazodone
Vorapaxar
Vortioxetine
Warfarin
Yohimbine
Ziprasidone
Zolmitriptan
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol
Phenprocoumon

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

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Description and Brand Names
Proper Use

Portions of this document last updated: Aug. 01, 2024